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EZH2
Anti-EZH2 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- PE-A*02:01/Human EZH2 (YMCSFLFNL) MHC Tetramer (MHC-LC078)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: YMCSFLFNL
- Conjugate: PE
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- APC-A*02:01/Human EZH2 (YMCSFLFNL) MHC Tetramer (MHC-LC079)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: YMCSFLFNL
- Conjugate: APC
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- Rabbit Anti-EZH2 Recombinant Antibody (clone CBACN-338) (MRO-0905-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Rabbit Anti-EZH2 Recombinant Antibody (VS3-WK1001) (VS3-WK1001)
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- PE-A*02:01/Human EZH2 (SQADALKYV) MHC Tetramer (MHC-CN0657)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: SQADALKYV
- Conjugate: PE
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- APC-A*02:01/Human EZH2 (SQADALKYV) MHC Tetramer (MHC-CN0658)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: SQADALKYV
- Conjugate: APC
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- FITC-A*02:01/Human EZH2 (SQADALKYV) MHC Tetramer (MHC-CN0659)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: SQADALKYV
- Conjugate: FITC
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- A*02:01/Human EZH2 (SQADALKYV) MHC Tetramer (MHC-CN0660)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: SQADALKYV
- Conjugate: Unconjugated
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- A*02:01/Human EZH2 (YMCSFLFNL) MHC Monomer (MHC-YF275)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: YMCSFLFNL
- Conjugate: Biotin
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- A*02:01/Human EZH2 (SQADALKYV) MHC Pentamer (MHC-YF430)
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- Class: Class I
- Antigen: EZH2
- Antigen Species: Human
- Peptide: SQADALKYV
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Mouse Anti-NHP EZH2 Recombinant Antibody (clone H.547.3) (VS-1024-XY197)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC1 and HDAC2. Binds ATRX via the SET domain (Probable). Interacts with PRAME. Interacts with CDYL. Interacts with CLOCK, ARNTL/BMAL1 and CRY1 (By similarity). Interacts with DNMT3L; the interaction is direct (By similarity). Interacts with EZHIP; the interaction blocks EZH2 methyltransferase activity (PubMed:30923826, 31086175, 31451685). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (PubMed:32051553). Interacts with ARMC12 (PubMed:30026490).
Molecular function
Chromatin regulator, Methyltransferase, Repressor, Transferase
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