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EPHB6

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants.
Protein class

Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Muller glia cells, Suprabasal keratinocytes, Sertoli cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Group enriched (MOLT-4, RT4)

Interaction

Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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