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FRS2
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- Anti-FRS2 Immunohistochemistry Kit (VS-0525-XY2651)
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- Species Reactivity: Human
- Target: FRS2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include Retinitis Pigmentosa 32 and Inflammatory Mfh. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include insulin receptor binding and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is FRS3.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds RET (By similarity). Binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding).
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