GD2 & CD3
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. The relatively tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors.
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
Species Reactivity: Mouse
Type: Rat IgG2b, κ
Application: FC, IHC, IP, Activ, CMCD, Depletion
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Species Reactivity: Human
Type: Mouse IgG
Application: FC, ELISA, FuncS
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, WB, FuncS
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, WB, FuncS
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, WB, FuncS
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Species Reactivity: Human
Type: Mouse scFv
Application: FC, ELISA, FuncS
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Species Reactivity: Human
Type: Mouse IgG
Application: WB, FuncS
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Species Reactivity: Human
Type: Mouse Fab
Application: FC, ELISA, FuncS
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Species Reactivity: Human
Type: Mouse Fab
Application: WB, FuncS
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Species Reactivity: Human
Type: Mouse scFv
Application: WB, FuncS
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Target: GD2
Species Reactivity: Human
Cytokine 1: TNFα
Host: Chimeric (Human-Mouse)
Cytokine 1 Species: Human
Molecule Class: L Kappa; IgG1-TNFα
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL2
Host: Chimeric (Human-Mouse)
Cytokine 1 Species: Human
Molecule Class: L Kappa; IgG1-IL2
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL12
Cytokine 2: IL2
Host: Mouse
Cytokine 1 Species: Mouse
Cytokine 2 Species: Mouse
Molecule Class: L kappa; IgG1-IL12-IL2
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL12
Cytokine 2: IL2
Host: Mouse
Cytokine 1 Species: Human
Cytokine 2 Species: Human
Molecule Class: L kappa; IgG1-IL12-IL2
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Target: GD2
Species Reactivity: Human
Cytokine 1: LT
Host: Chimeric (Human-Mouse)
Cytokine 1 Species: Human
Molecule Class: L Kappa; IgG1-LT
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Target: GD2
Species Reactivity: Human
Cytokine 1: RLI
Host: Chimeric (Human-Mouse)
Cytokine 1 Species: Human
Molecule Class: L Kappa; IgG2-RLI
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL12
Host: Mouse
Cytokine 1 Species: Human
Molecule Class: IgG2-IL12
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL2
Host: Chimeric (Mouse-Dog)
Cytokine 1 Species: Dog
Molecule Class: scFv-Fc-IL2
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL12
Cytokine 2: IL2
Host: Mouse
Cytokine 1 Species: Human
Cytokine 2 Species: Human
Molecule Class: IgG3-IL12-IL2
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Target: GD2
Species Reactivity: Human
Cytokine 1: IL12
Host: Mouse
Cytokine 1 Species: Human
Molecule Class: IgG2-ala-IL12
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For Research Use Only. Not For Clinical Use.