Anti-GOT1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs can help advance your cancer metabolism research with our anti-GOT1 recombinant antibodies. Glutamic-Oxaloacetic Transaminase 1 (GOT1) is a critical cytosolic transaminase, involved in amino acid metabolism and redox homeostasis. These high-quality antibodies will help you understand how cancer cells reprogram metabolism to fuel proliferation, especially under metabolic stress conditions.

GOT1: A Cytosolic Hub for Amino Acid Metabolism and Redox Balance

Glutamic-Oxaloacetic Transaminase 1 (GOT1), also known as aspartate aminotransferase 1 (AST1), is the cytosolic isoform of aspartate aminotransferase (AST). GOT1 catalyzes the reversible transamination between aspartate and α-ketoglutarate, yielding oxaloacetate and glutamate. GOT1 connects amino acid metabolism to the Krebs cycle and plays a significant role in maintaining cellular redox homeostasis. In cancer cells with KRAS mutations, GOT1 is a part of a metabolic rewiring that supports cell proliferation under nutrient-limiting conditions by maintaining redox homeostasis (producing NADPH) and enabling the synthesis of macromolecules necessary for cell proliferation. As such, GOT1 presents an attractive metabolic target for cancer therapy development.

Alternative Names

Glutamic-Oxaloacetic Transaminase 1; Glutamate Oxaloacetate Transaminase 1; Glutamic-Oxaloacetic Transaminase 1, Soluble; Cysteine Aminotransferase, Cytoplasmic; Cysteine Transaminase, Cytoplasmic; Aspartate Aminotransferase 1; Aspartate Transaminase 1; Transaminase A; EC 2.6.1.1; CAspAT

Background

Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.

Anti-GOT1 rAb Products

Creative Biolabs' anti-GOT1 recombinant antibodies are engineered with the utmost specificity, rigorously validated for detection of the cytosolic GOT1 isoform without cross-reactivity to the mitochondrial GOT2 isoform. This level of precision is critical for studies that focus on metabolic compartmentalization. Our rAbs are validated and optimized for Western Blot and IHC applications and will provide you with high-quality and reproducible data for your cancer metabolism studies.

Table 1. Featured anti-GOT1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs employs leading-edge production platforms to keep pace with rapidly developing fields such as cancer metabolism. Our anti-GOT1 recombinant antibodies are produced in highly optimized systems to ensure that they recognize the native enzyme of interest, providing you with a specific and active tool for your most demanding experiments.

Featured Anti-GOT1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-GOT1 recombinant antibody production.

Fig.2 Gram-scale anti-GOT1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting scientific discovery by providing a variety of flexible antibody modalities. Our anti-GOT1 recombinant antibodies are available in a variety of customizable modalities to fit the needs of your experiments, enabling researchers around the world to study this critical metabolic enzyme in cancer.

Fig.3 Full-length anti-GOT1 recombinant antibody production and modalities.

Investigate cancer metabolism with Creative Biolabs' high-quality, isoform-specific anti-GOT1 recombinant antibodies. Our selection is validated to provide you with the specificity and confidence needed to study this important enzyme. Contact our scientific team today.