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GP6

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Early spermatids, Macrophages, Inhibitory neurons, Excitatory neurons, Late spermatids, Cone photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HEL, K-562, U-2 OS)

Interaction

Associated with Fc receptor gamma chain. The GPVI:FcRgamma complex is associated with the Src kinase family FYN and LYN (PubMed:10961879, PubMed:9295288). Interacts with TRAF4 (PubMed:20946164). Interacts with COL1A1, but not with COL4A4 (By similarity). (Microbial infection) Interacts with Staphylococcus aureus protein SSL5.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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