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    GP6

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11).
    Protein class

    Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Early spermatids, Macrophages, Inhibitory neurons, Excitatory neurons, Late spermatids, Cone photoreceptor cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (HEL, K-562, U-2 OS)

    Interaction

    Associated with Fc receptor gamma chain. The GPVI:FcRgamma complex is associated with the Src kinase family FYN and LYN (PubMed:10961879, PubMed:9295288). Interacts with TRAF4 (PubMed:20946164). Interacts with COL1A1, but not with COL4A4 (By similarity). (Microbial infection) Interacts with Staphylococcus aureus protein SSL5.

    Molecular function

    Receptor

    More Types Infomation
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