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Anti-GPC3 Recombinant Antibody Products

Anti-GPC3 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs offers a diverse range of top-notch anti-GPC3 recombinant antibodies, meticulously engineered to deliver superior performance. Our cutting-edge platform ensures exceptional specificity, stability, and efficacy, making these antibodies invaluable assets for researchers and developers in the field of targeted cancer therapy.

GPC3: An Attractive Target for Cancer Therapy

Glypican-3 (GPC3) is a protein primarily expressed during embryonic development and in hepatocellular carcinoma (HCC) tumor cells. Its unique expression pattern, absent in most normal adult tissues and liver diseases like fatty liver, cirrhosis, hepatitis, or liver damage, makes GPC3 an ideal target for both diagnosing and treating HCC. This specificity allows for the development of diagnostic tools and therapeutic strategies that selectively target HCC cells, minimizing harm to healthy tissues.

Alternative Names

Glypican-3; Glypican 3; DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1.

Background

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Protein class

Cancer-related genes, Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Fibroblasts, Syncytiotrophoblasts, Muller glia cells, Cytotrophoblasts, Extravillous trophoblasts)

Immune cell specificity

Immune cell enhanced (naive CD4 T-cell, naive CD8 T-cell)

Cell line specificity

Group enriched (HAP1, Hep G2)

Interaction

Heterodimer; disulfide-linked (PubMed:14610063). Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer (PubMed:14610063). Interacts with DPP4 (PubMed:17549790). Interacts with FGF2 (By similarity). Interacts with WNT5A (PubMed:14610063). Also interacts with WNT3A and WNT7B (PubMed:16227623). Interacts with hedgehog protein SHH; the heparan sulfate chains are not required for the interaction (By similarity). Also interacts with hedgehog protein IHH (By similarity). Interacts with CD81 (By similarity). Interacts with Wnt receptors FZD4, FZD7 and FZD8; the heparan sulfate chains are required for the interaction (PubMed:24496449).

Molecular function

Protease inhibitor

More Types Infomation

Anti-GPC3 rAb Products

Creative Biolabs provides a collection of recombinant anti-GPC3 antibodies that have been rigorously developed to display high specificity and affinity. These antibodies are available in a variety of forms and are designed for a wide range of studies and therapeutic applications, spanning basic research to therapeutic development. Based on our robust platform, we deliver cutting-edge tools to advance the research of immunology, cancer biology, and related topics, as well as facilitate therapeutics development.

Table 1. Featured anti-GPC3 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
FAMAB-0560WJ Human Anti-GPC3 Recombinant Antibody (clone hYP9.1) Human Human IgG1, κ ELISA, WB
HPAB-0561-CN-S(P) Mouse Anti-GPC3 Recombinant Antibody (clone GC33); scFv Fragment Human Mouse scFv ELISA
AFC-TAB-H14 Afuco™ Anti-GPC3 ADCC Recombinant Antibody (Codrituzumab), ADCC Enhanced Human Human, ADCC-enhanced antibody FuncS, IF, Neut, ELISA, FC, IP
HPAB-0563-CN Human Anti-GPC3 Recombinant Antibody (clone hGC33) Human Humanized IgG1, κ ELISA
TAB-157CT Human Anti-GPC3 Recombinant Antibody (TAB-157CT) Human, Cynomolgus monkey, Rat, Mouse Human, Chimeric (mouse/human) IgG1 ELISA, FC, IHC, WB
HPAB-0561-CN Mouse Anti-GPC3 Recombinant Antibody (clone GC33) Human Mouse IgG ELISA

Creative Quality Control

Creative Biolabs provides a complete spectrum of anti-GPC3 recombinant antibodies that have undergone rigorous quality testing. Our cutting-edge facilities and expert scientists precisely develop each antibody to target GPC3 with pinpoint accuracy. Through rigorous testing and validation, we ensure that these antibodies exhibit superior specificity, strong binding affinity, and other optical properties in a wide range of research applications.

Fig.1 WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-GPC3 antibody
(Cat# HPAB-0561-CN, Creative Biolabs).

Fig.2 ELISA analysis. (Creative Biolabs Original)Fig.2 ELISA analysis of anti-GPC3 antibody
(Cat# HPAB-0561-CN, Creative Biolabs).

Fig.3 WB analysis. (Creative Biolabs Original)Fig.3 WB analysis of anti-GPC3 antibody
(Cat# ZG-0690J, Creative Biolabs).

Fig.4 IF analysis. (Creative Biolabs Original)Fig.4 IF analysis of anti-GPC3 antibody
(Cat# ZG-0690J, Creative Biolabs).

Fig.5 WB analysis. (Creative Biolabs Original)Fig.5 WB analysis of anti-GPC3 antibody
(Cat# TAB-263CQ, Creative Biolabs).

Fig.6 ELISA analysis. (Creative Biolabs Original)Fig.6 ELISA analysis of anti-GPC3 antibody
(Cat# TAB-263CQ, Creative Biolabs).

Customer Reviews

Excellent
X Zh***g
Mouse Anti-GPC3 Recombinant Antibody (clone GC33) (HPAB-0561-CN)
Creative Biolabs' anti-GPC3 recombinant antibody performed admirably in our ELISA testing. The antibody demonstrated outstanding specificity and sensitivity, allowing us to quantify GPC3 levels in an array of biological samples precisely. This antibody's constant performance and ease of usage greatly improved our research productivity and data quality.
20/Feb/2022
Excellent
T* Sh**h
Human Anti-GPC3 Recombinant Antibody (clone hGC33) (HPAB-0563-CN)
We were impressed with the quality and performance of Creative Biolabs' anti-GPC3 recombinant antibody. When used in our ELISA assays, it yielded robust and reproducible results. The antibody's strong binding affinity and high specificity enabled us to detect and quantify GPC3, even at low concentrations confidently. We highly recommend this product for researchers working on HCC research.
6/Aug/2023
Excellent
Yv***e
Human Anti-GPC3 Recombinant Antibody (HPAB-0692-WJ) (HPAB-0692-WJ)
We have been highly satisfied with Creative Biolabs' anti-GPC3 recombinant antibody for both Western Blot and Flow cytometry applications. The antibody consistently delivers strong, specific bands in WB analysis, enabling accurate protein detection. In flow cytometry, it provides clear and distinct staining of GPC3-positive cells, facilitating precise cell population analysis. The versatility and reliability of this antibody have been invaluable in our research efforts.
9/Nov/2023

rAb Production

Creative Biolabs provides a consistent supply of superior anti-GPC3 antibodies that are produced using cutting-edge genetic technologies.

Featured Anti-GPC3 Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
Fig.7 Milligram-scale anti-GPC3 recombinant antibody production.

Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-GPC3 recombinant antibody production.

rAb Modalities

Creative Biolabs provides a wide range of high-quality anti-GPC3 recombinant antibodies with diverse formats to meet global researchers’ various demands.

Fig.9 GPC3 antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-GPC3 recombinant antibody production and modalities.

GPC3-Targeted Drug Information

Table 2. Public drug targeting GPC3.

Highest Phase Mechanism of Action Product Category Condition Organization
National Cancer Center of Japan (Originator) Phase II Cancer Immunotherapy
Cancer Vaccines
Oligopeptides, less than 10 AA
Peptide Vaccines
Cancer, liver (hepatocellular carcinoma)
National Cancer Center of Japan (Originator) Phase II Cancer Immunotherapy
Cancer Vaccines
Oligopeptides, less than 10 AA
Peptide Vaccines
Cancer, liver (hepatocellular carcinoma)
Creagene (JW Creagene)
JW Creagene (Originator)
Phase II Cancer Immunotherapy
Cancer Vaccines
Dendritic Cell Vaccines
Cancer, liver
Chugai Pharmaceutical (Originator)
Roche (Originator)
Phase II Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, liver
Cancer, liver (hepatocellular carcinoma)
AbelZeta
AstraZeneca (Originator)
Phase I/II Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells)
Cancer, liver (hepatocellular carcinoma)
Sanofi (Originator) Phase I/II Cancer Immunotherapy
Single-Domain Antibodies
Cancer, liver (hepatocellular carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, solid tumor
KeyMed Biosciences (Originator) Phase I/II Bispecific Antibodies
Cancer Immunotherapy
Cancer, solid tumor
OriCell Therapeutics (Originator) Phase I/II Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Cancer, liver (hepatocellular carcinoma)
Eureka Therapeutics (Originator) Phase I/II Adoptive Cell Therapy
Cancer Immunotherapy
Cancer, liver (hepatocellular carcinoma)
Cogent Biosciences (Originator)
SOTIO Biotech
SOTIO (SOTIO Biotech)
Unum Therapeutics (Cogent Biosciences)
Phase I/II Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Cancer, liver (hepatocellular carcinoma)
Cancer, lung (non-small cell) (NSCLC) (squamous cell carcinoma)
Cancer, solid tumor
Carcinoma, Merkel cell
Liposarcoma, myxoid-round cell

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

For more information or to inquire about our anti-GPC3 recombinant antibody products, please contact us at any time.

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