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GPR143
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- PE-A*24:02/Human GPR143 (LYSACFWWL) MHC Tetramer (MHC-LC3295)
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- Class: Class I
- Antigen: GPR143
- Antigen Species: Human
- Peptide: LYSACFWWL
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Melanocytes, Cytotrophoblasts)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enriched (SK-MEL-30)
Interaction
Interacts with heterotrimeric G(i) proteins. Interacts with ARRB1 and ARRB2. Interacts with MLANA.
Molecular function
G-protein coupled receptor, Receptor, Transducer
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