Cancer-related genes, Disease related genes, Human disease related genes
Intracellular, Secreted (different isoforms)
Cell type enhanced (Skeletal myocytes, Spermatogonia, Fibroblasts, Theca cells)
Not detected in immune cells
Cell line enhanced (hTEC/SVTERT24-B, SuSa, U-87 MG, WM-115)
Homodimer; disulfide-linked (PubMed:8493557, PubMed:8988018, PubMed:19478429). Interacts with RET (PubMed:21994944). Interacts (via propeptide) with SORL1 (via N-terminal ectodomain); this interaction affects GDNF-regulated, but not constitutive secretion (PubMed:15364913, PubMed:21994944, PubMed:23333276). Also interacts with SORL1 in complex with GFRA1; this interaction leads to GDNF endocytosis and lysosomal degradation (PubMed:23333276).
Growth factor
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For Research Use Only. Not For Clinical Use.