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GZMA

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
Protein class

Enzymes

Predicted location

Secreted

Single cell type specificity

Group enriched (NK-cells, dendritic cells, T-cells)

Immune cell specificity

Group enriched (gdT-cell, MAIT T-cell, memory CD8 T-cell, NK-cell, naive CD8 T-cell, memory CD4 T-cell)

Cell line specificity

Cell line enhanced (HL-60, JURKAT)

Interaction

Homodimer; disulfide-linked (PubMed:12819769, PubMed:12819770). Interacts with APEX1 (PubMed:12524539).

Molecular function

Hydrolase, Protease, Serine protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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