Cancer-related genes, Disease related genes
Intracellular
Cell type enriched (Late spermatids)
Group enriched (basophil, neutrophil, eosinophil, plasmacytoid DC, NK-cell)
Cell line enhanced (A549)
Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A AND GRIN2B.
Actin-binding, Activator
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For Research Use Only. Not For Clinical Use.