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HIST1H4A
Anti-HIST1H4A Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein class
Disease related genes
Predicted location
Intracellular
Single cell type specificity
Not detected
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Cell line enhanced (MOLT-4, NB-4, REH)
Interaction
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (PubMed:33857403). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (PubMed:33857403).
Molecular function
DNA-binding
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