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HNRNPA1
Anti-HNRNPA1 Recombinant Antibody Products
- Rabbit Anti-HNRNPA1 Recombinant Antibody (clone JA39-21) (MRO-0759-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- AbPlus™ Anti-HNRNPA1 Magnetic Beads (4B10) (VS-0424-XY127)
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- Target: HNRNPA1
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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- Mouse Anti-NHP HNRNPA1 Recombinant Antibody (clone 9H10) (VS-1024-XY253)
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- Species Reactivity: Bovine, Dog, Hamster, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG2b
- Application: WB, IF
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- Anti-HNRNPA1 Immunohistochemistry Kit (VS-0325-XY1040)
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- Species Reactivity: Human, Rat
- Target: HNRNPA1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with SEPT6 (PubMed:17229681). Interacts with C9orf72 (PubMed:24549040). Interacts with KHDRBS1 (PubMed:17371836). Interacts with UBQLN2 (PubMed:25616961). Interacts with PPIA/CYPA (PubMed:25678563). Interacts (via the RGG-box) with the HOXB-AS3 peptide; the interaction inhibits binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene, preventing inclusion of exon 9 and promoting inclusion of exon 10 which suppresses formation of the PKM M2 isoform and promotes production of the M1 isoform (PubMed:28985503). (Microbial infection) Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. (Microbial infection) May interact with SARS-CoV Nucleoprotein.
Molecular function
Ribonucleoprotein, RNA-binding
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