Anti-HSD11B1 Recombinant Antibody Products

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Anti-HSD11B1 Products

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For Research Use Only. Not For Clinical Use.

At Creative Biolabs, we are committed to empowering global researchers with high-quality and reliable reagents. Our extensive portfolio includes a specialized range of anti-HSD11B1 recombinant antibody products designed to meet the rigorous demands of modern biological research. Engineered for exceptional specificity and consistency, these antibodies are indispensable tools for advancing studies in metabolic diseases, bone health, and steroid hormone regulation. We provide solutions that accelerate scientific discovery worldwide.

HSD11B1: A Crucial Target for Metabolic and Bone-Related Therapies

HSD11B1 (11β-hydroxysteroid dehydrogenase type 1) is a key enzyme that converts inactive cortisone into active cortisol, thus regulating local glucocorticoid levels within specific tissues. This local amplification of glucocorticoid action is crucial for a variety of physiological processes. Extensive research now highlights its significant role in metabolic regulation and cell differentiation pathways, particularly in adipose tissue and bone. By studying HSD11B1, scientists can gain deeper insights into its contribution to complex conditions such as obesity, type 2 diabetes, and age-related osteoporosis, thereby paving the way for the development of innovative therapeutic strategies targeting this critical enzyme.

Alternative Names

11β-Hydroxysteroid dehydrogenase type 1; 11-DH; 11-beta-HSD1; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1; hydroxysteroid (11-beta) dehydrogenase 1; hydroxysteroid 11-beta dehydrogenase 1.

Background

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Anti-HSD11B1 rAb Products

Our recombinant anti-HSD11B1 antibodies are meticulously developed to offer superior performance and reliability. Unlike conventional polyclonal antibodies, our products are produced using a proprietary recombinant expression platform, ensuring batch-to-batch consistency and exceptional specificity. This guarantees that your research results are reproducible and accurate, saving you valuable time and resources while providing clear, interpretable data for your experiments.

Table 1. Featured anti-HSD11B1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

We implement a rigorous, multi-stage quality control process to guarantee the superior performance of every anti-HSD11B1 recombinant antibody. Each product undergoes thorough validation using multiple techniques, including ELISA, Western Blotting, and immunohistochemistry. This stringent quality assurance ensures high specificity, low background noise, and optimal sensitivity, providing you with a reliable tool for your research needs.

Customer Reviews

Excellent

Je***ns
Recombinant Mouse Anti-Human HSD11B1 Antibody (MOB-1138MZ)

We've been using Creative Biolabs' anti-HSD11B1 antibody for our Western Blotting assays, and the results are consistently outstanding. The specificity is impeccable, with a strong, clean band exactly where we expect it. It's truly a high-quality product that has significantly streamlined our research workflow and improved the quality of our data. I highly recommend it to any lab working on metabolic targets.

20/Oct/2024

Excellent

Da**d
Rabbit Anti-HSD11B1 Recombinant Antibody (clone DS1678AB) (MOR-1678)

The experience of using this recombinant antibody for our immunofluorescence studies was flawless. The signal-to-noise ratio was excellent, allowing us to visualize HSD11B1 expression with remarkable clarity. We observed minimal non-specific binding, which is a common issue with other antibodies we've tested. This product has become an essential part of our research on HSD11B1 localization in different cell types.

28/Oct/2024

Excellent

Ro***ts
Rabbit Anti-HSD11B1 Recombinant Antibody (clone JU18-39) (MRO-0769-CN)

Creative Biolabs' anti-HSD11B1 antibody has been a game-changer for our functional assays in primary cell cultures. The antibody performed exceptionally well, and the high purity meant we could use it for sensitive applications without concern for cross-reactivity. The data we've generated has been highly consistent and robust, giving us confidence in our findings on glucocorticoid metabolism in various disease models.

12/Nov/2024

rAb Production

Our anti-HSD11B1 recombinant antibodies are produced using a high-performance recombinant expression system. This advanced technology ensures a highly controlled and scalable manufacturing process, resulting in products with superior purity, affinity, and stability. This method avoids the ethical concerns and batch variability associated with traditional animal-derived antibodies, providing a reproducible and reliable product every time.

Featured Anti-HSD11B1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-HSD11B1 recombinant antibody production.

Fig.2 Gram-scale anti-HSD11B1 recombinant antibody production.

rAb Modalities

We offer our anti-HSD11B1 recombinant antibody products in multiple modalities, including conjugated forms for direct detection, providing enhanced flexibility and convenience for various research applications.

Fig.3 Full-length anti-HSD11B1 recombinant antibody production and modalities.

At Creative Biolabs, we're committed to accelerating your research and development journey. Our anti-HSD11B1 recombinant antibody products are a testament to our commitment to quality and innovation. If you have any questions or require custom solutions tailored to your specific research goals, please do not hesitate to contact us. We are ready to assist you in accelerating your discoveries.