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HSD11B1

Anti-HSD11B1 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: ELISA, WB
- Recombinant Mouse Anti-Human HSD11B1 Antibody (MOB-1138MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
- Rabbit Anti-HSD11B1 Recombinant Antibody (clone JU18-39) (MRO-0769-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
- Chicken Anti-HDL Polyclonal IgY (BRD-0250MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Immune cell enhanced (memory CD4 T-cell)
Cell line specificity
Cell line enriched (ASC diff)
Interaction
Homodimer.
Molecular function
Oxidoreductase
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