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HSD17B8

Anti-HSD17B8 Products
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
- Anti-HSD17B8 Immunohistochemistry Kit (VS-0525-XY3290)
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- Species Reactivity: Human
- Target: HSD17B8
- Application: IHC
- Anti-Mouse HSD17B8 Immunohistochemistry Kit (VS-0525-XY3291)
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- Species Reactivity: Human, Mouse, Rat
- Target: HSD17B8
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (RPMI-8226, T-47d, U-266/70)
Interaction
Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.
Molecular function
Oxidoreductase
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