Histone H3K4me1

Histone H3 is a core component of the nucleosome, which serves as the fundamental unit of chromatin. Each nucleosome is a compact structure, comprising 147 base pairs of DNA tightly wrapped around an octamer of core histone proteins. This octamer includes two copies each of Histone H2A, Histone H2B, Histone H3, and Histone H4.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.