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IAPP
The antibodies specific for IAPP are used for the treatment and diagnosis of diseases from the group of Diabetes mellitus diseases, comprising type 1 diabetes (T1D), gestational diabetes, pre-diabetes, latent autoimmune diabetes of adults (LAD A; type 1, 5 diabetes) and/or type 2 diabetes (T2D).
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Early spermatids, Pancreatic endocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (U-2 OS)
Interaction
Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.
Molecular function
Hormone
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, IF, IHC
- Human Anti-IAPP Recombinant Antibody (clone HlLl); Fab Fragment (HPAB-0295-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized Fab
- Application: FuncS
- Recombinant Mouse Anti-IAPP Soluble TCR (BDC-5.2.9) (KIH) (VS-0622-YF6438)
-
- Species Reactivity: Mouse
- Epitope: KCNTATCATQRLANFLVRSS
- MHC: HLA class II
- Recombinant Mouse Anti-IAPP Soluble TCR (BDC-5.2.9) (C-Cys) (VS-0622-YF3730)
-
- Species Reactivity: Mouse
- Epitope: KCNTATCATQRLANFLVRSS
- MHC: HLA class II
- Mouse Anti-IAPP Recombinant Soluble TCR (BDC-5.2.9) (scTCR-267ZP-S(P))
-
- Species Reactivity: Mouse
- Epitope: KCNTATCATQRLANFLVRSS
- MHC: HLA class II
- Human Anti-IAPP Recombinant Antibody (clone HlLl); scFv Fragment (HPAB-0295-YC-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized scFv
- Application: FuncS
-
- Species Reactivity: Mouse
- Epitope: KCNTATCATQRLANFLVRSS
- MHC: HLA class II
- Human Anti-IAPP Recombinant Antibody (clone HlLl) (HPAB-0295-YC)
-
- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized IgG1, κ
- Application: FuncS
- Human Anti-IAPP Recombinant Antibody (TAB-120CT) (TAB-120CT)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody (TAB-119CT) (TAB-119CT)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody (TAB-118CT) (TAB-118CT)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody; scFv Fragment (TAB-120CT-S(P)) (TAB-120CT-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody; scFv Fragment (TAB-119CT-S(P)) (TAB-119CT-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody; scFv Fragment (TAB-118CT-S(P)) (TAB-118CT-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
-
- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Human Anti-IAPP Recombinant Antibody; Fab Fragment (TAB-120CT-F(E)) (TAB-120CT-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody; Fab Fragment (TAB-119CT-F(E)) (TAB-119CT-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody; Fab Fragment (TAB-118CT-F(E)) (TAB-118CT-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-IAPP Recombinant Antibody (TAB-375CL) (TAB-375CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.