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IFI16

Anti-IFI16 Products
- Recombinant Mouse Anti-Human IFI16 Antibody (MOB-2320MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
- Anti-IFI16 Immunohistochemistry Kit (VS-0325-XY1093)
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- Species Reactivity: Human, Mouse, Rat
- Target: IFI16
- Application: IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IHC-P, WB
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms homooligomers; isoform 2 can self-associate or associate with isoform 1 or isoform 3. Interacts with TMEM173, AIM2, PYCARD and CASP1. Interacts with BRCA1, TP53, E2F1, RB1 and SP1. Interacts with MTA1. Interacts with PYDC5 (PubMed:24531343).
Molecular function
Activator, DNA-binding, Repressor
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