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IFNB1

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This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection.

Species Reactivity:
Human
Type:
IgG1
Application:
Neut, WB
Species Reactivity:
Human
Type:
IgG1, κ
Application:
FuncS, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
ELISA, Neut, WB
Species Reactivity:
Human
Type:
IgG2a
Application:
Neut
Species Reactivity:
Human
Type:
IgG1
Application:
WB, Neut, ELISA
Species Reactivity:
Human
Type:
IgG1
Application:
WB, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
Neut
Species Reactivity:
Human
Type:
IgG1
Application:
Neut
Species Reactivity:
Human
Type:
IgG2a
Application:
ELISA(Cap), BL
Species Reactivity:
Human
Type:
IgG1, κ
Application:
WB, ELISA, Neut
Species Reactivity:
Human
Type:
IgG1, κ
Application:
Neut, ELISA
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA, Neut
Species Reactivity:
Mouse
Type:
IgG
Application:
Neut
Species Reactivity:
Mouse
Type:
IgG
Application:
WB, Neut
Species Reactivity:
Mouse
Type:
IgG1
Application:
WB, ELISA, FC, Neut
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB, IP
Species Reactivity:
Human
Application:
ELISA, Neut
Protein Chemical Formula:
C908H1408N246O252S7
Protein Average Weight:
20027.0 Da
CAS Number:
145258-61-3
Protein Chemical Formula:
C908H1408N246O253S6
Protein Average Weight:
20011.0 Da
CAS Number:
145155-23-3
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, FC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, WB, FuncS
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