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IGF1R
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Related Signaling Pathways
Insulin Signaling Pathway
Related Diseases
Endocrine Resistance
Type I Diabetes Mellitus
- Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) (NEUT-1075CQ)
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- Species Reactivity: Hamster, Human
- Type: Mouse IgG1
- Application: FC, IP, Neut, ICC, IF
Compare
- Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) (NEUT-1076CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Neut, WB
Compare
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP, ELISA
Compare
- Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) (NEUT-1077CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, Block, IHC, IP, WB
Compare
- Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) (NEUT-1078CQ)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a, κ
- Application: Inhib, ICC, IF, IP, WB
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E)) (TAB-086ZJ-F(E))
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- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, FC, Inhib, IP
Compare
- Human Anti-IGF1R Recombinant Antibody (HPAB-0085-YC) (HPAB-0085-YC)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Block, FuncS, FC, ELISA
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c) (TAB-085ZJ-F(E))
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, Neut, FC, IHC
Compare
- Human Anti-IGF1R Recombinant Antibody (HPAB-0084-YC) (HPAB-0084-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E)) (TAB-084ZJ-F(E))
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- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, FC
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (1A) (TAB-058ZJ-F(E))
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- Species Reactivity: Marmoset monkey, Cynomolgus monkey, Human
- Type: Human antibody
- Application: ELISA
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-057ZJ-F(E)) (TAB-057ZJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
- Anti-Human IGF-1R Recombinant Antibody (1A) (TAB-058ZJ)
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- Species Reactivity: Marmoset monkey, Cynomolgus monkey, Human
- Type: Human antibody
- Application: FC, WB
Compare
- Chicken Anti-CD221 Polyclonal IgY (BRD-0103MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-056ZJ-F(E)) (TAB-056ZJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-055ZJ-F(E)) (TAB-055ZJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
- IGF1-DT immunotoxin (AGTO-L024D)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA
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- IGF1-PE immunotoxin (AGTO-L024E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Compare
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Compare
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - lambda
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Compare
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG2 - kappa
- Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Compare
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (IR10) (TAB-054ZJ-F(E))
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- Derivation: Fab phage library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, WB
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (IR3) (TAB-053ZJ-F(E))
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- Derivation: Fab phage library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, WB
Compare
- Anti-Human IGF-1R Recombinant Antibody (IR10) (TAB-054ZJ)
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- Derivation: Fab phage library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, WB
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR10) (TAB-054ZJ-S(P))
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- Derivation: Fab phage library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, WB
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (18) (TAB-052ZJ-F(E))
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, IF, IP
Compare
- Anti-Human IGF-1R Recombinant Antibody (IR3) (TAB-053ZJ)
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- Derivation: Fab phage library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, WB
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR3) (TAB-053ZJ-S(P))
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- Derivation: Fab phage library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, WB
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-051ZJ-F(E)) (TAB-051ZJ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized Fab
- Application: ELISA, IHC, IF, WB
Compare
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- Derivation: VHH phage library
- Species Reactivity: Rat, Human
- Type: Single domain antibody
- Application: ELISA, IHC, IF, WB
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- Anti-Human IGF-1R Recombinant Antibody (18) (TAB-052ZJ)
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- Species Reactivity: Human
- Type: Human antibody
- Application: IHC, ELISA, FC, IF, IP
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (18) (TAB-052ZJ-S(P))
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, IF, IP
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-038ZJ-F(E)) (TAB-038ZJ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, Inhib, IP
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (7C2) (TAB-016ZJ-F(E))
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- Species Reactivity: Human
- Application: IP, IHC, ELISA, FC
Compare
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized antibody
- Application: ELISA, IHC, IF, WB
Compare
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Human scFv
- Application: ELISA, IHC, IF, WB
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (H1L0 IgGIm(AA)) (TAB-037ZJ-F(E))
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, Neut, FC, IHC
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (9E11) (TAB-015ZJ-F(E))
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- Species Reactivity: Human
- Application: IP, IHC, ELISA, FC
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (H0L0 IgGIm(AA)) (TAB-036ZJ-F(E))
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, Neut, FC, IHC
Compare
- Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-014ZJ-F(E)) (TAB-014ZJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Inhib, IP
Compare
- Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-035ZJ-F(E)) (TAB-035ZJ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
Compare
- Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-012ZJ-F(E)) (TAB-012ZJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, Inhib
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (ch9E11) (TAB-093ZJ-S(P))
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
Compare
- Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-011ZJ-F(E)) (TAB-011ZJ-F(E))
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- Species Reactivity: Rhesus monkey, Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, Inhib
Compare
- Anti-Human IGF-1R Recombinant Antibody (7C2) (TAB-016ZJ)
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- Species Reactivity: Human
- Application: IP, IHC, ELISA, FC
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (ch7C2) (TAB-087ZJ-S(P))
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (7C2) (TAB-016ZJ-S(P))
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- Species Reactivity: Human
- Application: IP, IHC, ELISA, FC
Compare
- Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11) (TAB-010ZJ-F(E))
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- Species Reactivity: Human
- Application: ELISA, Neut, FC, IHC
Compare
- Anti-Human IGF-1R Recombinant Antibody (9E11) (TAB-015ZJ)
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- Species Reactivity: Human
- Application: FC, IP, IHC, ELISA
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (9E11) (TAB-015ZJ-S(P))
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- Species Reactivity: Human
- Application: IP, IHC, ELISA, FC
Compare
- Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-009ZJ-F(E)) (TAB-009ZJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (6E11c) (TAB-085ZJ-S(P))
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, Neut, FC, IHC
Compare
- Anti-Human IGF-1R Recombinant Antibody (ch9E11) (TAB-093ZJ)
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
Compare
- Anti-Human IGF-1R Recombinant Antibody (1H7) (TAB-013ZJ)
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- Species Reactivity: Human
- Application: WB, Inhib
Compare
- Anti-Human IGF-1R Recombinant Antibody (ch7C2) (TAB-087ZJ)
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (1A) (TAB-058ZJ-S(P))
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- Species Reactivity: Marmoset monkey, Cynomolgus monkey, Human
- Type: Human antibody
- Application: ELISA
Compare
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- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: ELISA, FC, Inhib, IP
Compare
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- Species Reactivity: Rhesus monkey, Human
- Type: Mouse IgG2, κ
- Application: ELISA, FC, WB, Inhib
Compare
- Anti-Human IGF-1R Recombinant Antibody scFv Fragment (6E11) (TAB-010ZJ-S(P))
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- Species Reactivity: Human
- Application: ELISA, Neut, FC, IHC
Compare
- Anti-Human IGF-1R Recombinant Antibody (6E11) (TAB-010ZJ)
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- Species Reactivity: Human
- Application: ELISA, Neut, FC, IHC
Compare
- Anti-Human IGF-1R Recombinant Antibody (6E11c) (TAB-085ZJ)
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC, IHC, Inhib
Compare
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