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IL11
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
Protein class
Cancer-related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Pancreatic endocrine cells, Smooth muscle cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, HBF TERT88, hTEC/SVTERT24-B, U-251 MG)
Interaction
Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex.
Molecular function
Cytokine, Growth factor
More Types Infomation
Related Diseases
Asthma
Rheumatoid Arthritis
- Recombinant Anti-human IL11 Antibody scFv Fragment (MOB-551-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
- Recombinant Anti-human IL11 Antibody Fab Fragment (MOB-551-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, RIA, FuncS
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- Species Reactivity: Human
- Application: sELISA
- Recombinant Human Anti-human IL11 Antibody Fab Fragment (MHH-551-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, Neut, FuncS
- Recombinant Human Anti-human IL11 Antibody scFv Fragment (MHH-551-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: FC, Neut, Funcs
- Rat Anti-Il11 Recombinant Antibody (clone CBL582) (NEUT-1150CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: Neut, WB
- Rat Anti-Il11 Recombinant Antibody (clone CBL089) (NEUT-1149CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: Neut, WB
- Rat Anti-Il11 Recombinant Antibody (clone 22C39) (NEUT-1148CQ)
-
- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: Neut, WB
- Mouse Anti-IL11 Recombinant Antibody (clone CBL432) (NEUT-1147CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, CyTOF, ICFC, Neut
- Mouse Anti-IL11 Recombinant Antibody (clone CBL265) (NEUT-1146CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Neut
- Mouse Anti-IL11 Recombinant Antibody (clone CBL088) (NEUT-1145CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2
- Application: Neut, WB
- Mouse Anti-IL11 Recombinant Antibody (clone 27B1047.1) (NEUT-1144CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, Neut, WB
- Mouse Anti-IL11 Recombinant Antibody (clone P107) (NEUT-1143CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: Neut, ELISA
- Mouse Anti-IL11 Recombinant Antibody (clone MM0361-9T27) (NEUT-1142CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2
- Application: WB, Neut
- Recombinant Anti-human IL11 Antibody (MOB-551)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.