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    IL1A&IL1B

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimers disease.
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaggedlandin and collagenase from synovial cells.
    IL1A&IL1B
    Related Diseases
    Rheumatoid Arthritis Rheumatoid Arthritis
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young
    Related Signaling Pathways
    TNF Signaling Pathway TNF Signaling Pathway
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