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IL1R1

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Protein class

Cancer-related genes, CD markers, Enzymes, FDA approved drug targets, Human disease related genes, Transporters

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Endometrial stromal cells, Langerhans cells, Hepatic stellate cells, Endometrial ciliated cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, HHSteC, HSkMC)

Interaction

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.

Molecular function

Hydrolase, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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