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IL2RA & CD3

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Anti-IL2RA & CD3 Products

  • IL2-DT immunotoxin (AGTO-L078D)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • IL2-RTA immunotoxin (AGTO-L078R)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • IL2-PE immunotoxin (AGTO-L078E)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • TRX4 (Gly-002CL)
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  • Anti-CD25-PBD ADC (ADC-113LZY)
    • Target: CD25
    • Drug: pyrrolobenzodiazepine (PBD) dimers
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For Research Use Only. Not For Clinical Use.


Background

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL2RA & CD3
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
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