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IL2RA

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The interleukin 2 receptor alpha chain (also known as CD25) is a protein that is encoded by the human IL2RA gene. The interleukin 2 receptor alpha chain (IL2RA) and beta chain (IL2RB) together with the common gamma chain (IL2RG) constitute the high affinity IL2 receptor. The homodimeric alpha chain (IL2RA) results in a low affinity receptor, while the homodimeric beta (IL2RB) chain produces an intermediate affinity receptor. Normally, integral membrane proteins, soluble IL2RA have been isolated and identified as being produced by extracellular proteolysis. Alternative spliced IL2RA mRNA has been isolated, but the significance of each mRNA is currently unknown. IL2RA is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes. Although IL2RA has been used as a marker to identify CD4+ FoxP3+ regulatory T cells in mice, it has been found that most resting memory T cells constitutively express IL2RA in humans. IL2RA is expressed in most B cell tumors, some acute non-lymphocytic leukemias, neuroblastomas, mastocytosis, and tumor infiltrating lymphocytes. It functions as a receptor for HTLV-1 and therefore is expressed in tumor cells of adult T-cell lymphoma/leukemia. Its soluble form (sIL-2R) may be elevated in these diseases and occasionally used to track disease progression. Daclizumab (trade name Zinbryta) is a therapeutic humanized monoclonal antibody used to treat adults with relapsing multiple sclerosis (MS). Daclizumab works by binding to CD25.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, IF, FuncS
Species Reactivity:
Mouse
Type:
Llama VHH
Application:
ELISA, IHC, FC, FuncS
Species Reactivity:
Human
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Scaffold Name:
Z-domain of protein A
Target:
CD25
Species Reactivity:
Human
Derivation:
Phage display
Derivation:
Chimeric (mouse/human)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Targets:
IL2RA & CD3
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Anti-CD25-PBD ADC (ADC-113LZY)
Target:
CD25
Drug:
pyrrolobenzodiazepine (PBD) dimers
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, IHC, FuncS
Derivation:
Chimeric (Human/Mouse)
Species Reactivity:
Human
Type:
Fab
Application:
WB, FuncS
Derivation:
Chimeric (Human/Mouse)
Species Reactivity:
Human
Type:
scFv
Application:
WB, FuncS
Type:
Human antibody
Application:
ELISA, FC
Type:
Human antibody
Application:
ELISA, FC
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