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Anti-IL2RB Recombinant Antibody Products

Anti-IL2RB Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


To accelerate IL-2RB-related research, Creative Biolabs offers a wide range of high-quality anti-IL2RB recombinant antibodies. These antibodies are produced using advanced technology to ensure high specificity, stability, and efficacy. As a result, they are valuable tools for researchers and developers working on targeted cancer therapies.

IL2RB: An Important Immunotherapeutic Target

Essential for immune system control, the Interleukin-2 receptor beta chain (IL2RB) is linked to a spectrum of disorders when dysfunctional. In autoimmune diseases, IL2RB's loss might cause the immune system to target normal tissues. Moreover, several tumors include this receptor, which influences the spread of malignant cells. IL2RB also affects the immune response to infections like TB. Development of focused therapies and improvement of patient care depend on an understanding of the many roles IL2RB performs.

Alternative Names

Interleukin-2 receptor subunit beta; CD122; IL15RB; P70-75; IMD63; IL2RB.

Background

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.

Anti-IL2RB rAb Products

Creative Biolabs provides a large range of recombinant anti-IL2RB antibodies that have been carefully engineered to have excellent affinity and remarkable specificity. From basic scientific research to cutting-edge medicinal developments, our many kinds of antibodies are meant to enable a wide spectrum of research uses. These antibodies serve as powerful tools to advance immunology, cancer biology, and allied sciences and help to build next-generation therapeutic solutions by using the advanced platform.

Table 1. Featured anti-IL2RB recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
TAB-639LC Human Anti-IL2RB Recombinant Antibody (TAB-639LC) Human Human, humanized antibody ELISA, FC, FuncS
TAB-640LC Human Anti-IL2RB Recombinant Antibody (TAB-640LC) Human Human, humanized antibody ELISA, FC, FuncS
TAB-637LC Mouse Anti-IL2RB Recombinant Antibody (TAB-637LC) Human, Monkey Mouse IgG1, κ ELISA, FC, FuncS
TAB-638LC Mouse Anti-IL2RB Recombinant Antibody (TAB-638LC) Human, Monkey Mouse IgG2b, κ ELISA, FC, FuncS
TAB-425CL Anti-Human IL2RB Recombinant Antibody (MiK-Beta-1) Human Humanized antibody WB, ELISA, etc.

Creative Quality Control

Creative Biolabs offers an extensive array of recombinant antibodies that specifically target IL2RB, expertly developed and rigorously validated for quality. Our state-of-the-art laboratory and experienced researchers are devoted to creating each antibody with accuracy, assuring precise targeting of IL2RB. With extensive validation methods in place, we guarantee that our antibodies demonstrate great specificity, robust binding affinity, and dependable performance across a broad variety of research applications, making them crucial tools for scientists in the field.

Fig.1 WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-IL2RB antibody
(Cat# TAB-425CL, Creative Biolabs).

Fig.2 ELISA analysis. (Creative Biolabs Original)Fig.2 ELISA analysis of anti-IL2RB antibody
(Cat# TAB-425CL, Creative Biolabs).

Customer Reviews

Excellent
Wa***n
Human Anti-IL2RB Recombinant Antibody (clone A23A41) (HPAB-1561WJ)
My recent ELISA experiments using the anti-IL2RB recombinant antibody from Creative Biolabs yielded outstanding results. The antibody's exceptional performance was evident in the clear signal differentiation, enabling precise quantification of IL-2 receptor levels across my samples. Its high sensitivity and minimal background interference proved invaluable, especially when analyzing samples at lower concentrations. The simplicity of usage and reliable, repeatable findings confirmed even more the importance of the antibody in my work. My research of immune responses now depends much on this anti-IL2RB antibody, which I want to use extensively in future projects.
23/Apr/2023
Excellent
Kr***r
Anti-Human IL2RB Recombinant Antibody (MiK-Beta-1) (TAB-425CL)
The anti-IL2RB recombinant antibody has proved to be an excellent aid in my Western blot study. The outcomes were impressive, displaying a distinct and well-defined band that matched the anticipated size of the IL-2RB protein. I appreciated the reduced background signal, which often complicates WB results with other antibodies. The antibody worked well even at low concentrations, and the detection was both quick and efficient. After several rounds of testing, I can confidently say that this antibody delivers consistent and reliable outcomes. It's a fantastic product for any researcher working in the field of immunology.
11/Jun/2024
Excellent
Mi***l
Mouse Anti-IL2RB Recombinant Antibody (clone MAKA41) (HPAB-2114-FY)
In my inhibitory studies, I recently utilized the anti-IL2RB recombinant antibody; the results made me very happy. The antibody had exceptional specificity, which clearly reduced IL-2 signaling as expected. Following the advised standards, I diluted the antibody, and the target activity clearly showed inhibition. Furthermore, the results were constant throughout numerous trials, which is very essential for the credibility of my work. All things considered, this antibody is now a mainstay in my work, and I strongly advise it to anybody researching IL-2 signaling pathways.
15/Nov/2024

rAb Production

Creative Biolabs offers a reliable range of high-quality anti-IL2RB antibodies that are carefully made utilizing state-of-the-art genetic engineering techniques. Every antibody is meticulously created to guarantee improved effectiveness and dependability for a range of research uses.

Featured Anti-IL2RB Recombinant Antibody Production PlatformsFig.3 Milligram-scale. (Creative Biolabs Original)
Fig.3 Milligram-scale anti-IL2RB recombinant antibody production.

Fig.4 Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-IL2RB recombinant antibody production.

rAb Modalities

To meet the various demands of researchers throughout the world, Creative Biolabs provides a comprehensive range of high-quality anti-IL2RB recombinant antibodies in a variety of forms.

Fig.5 IL2RB antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-IL2RB recombinant antibody production and modalities.

IL2RB-Targeted Drug Information

Table 2. Public drug targeting IL2RB.

Company Research phase Classification Condition
Cerimon
Novartis (Originator)
Launched - 1998 Chimeric Monoclonal Antibodies Cytokine release syndrome
Immunosuppression
Inflammatory bowel disease
Transplant rejection
Transplant rejection, kidney
Ulcerative colitis
Uveitis
Biogen (Originator)
Roche (Originator)
Shionogi
Launched - 1992 Cancer Immunotherapy
IL-2
Polypeptides, from 41 AA
Recombinant proteins
Angiosarcoma
Cancer, colorectal, metastatic
Abbott
AbbVie
Biogen
Biogen Idec (Biogen)
National Cancer Institute
National Eye Institute (NEI)
PDL BioPharma (Originator)
Protein Design Labs (PDL BioPharma)
Roche
UCB
Withdrawn - 2018 Cancer Immunotherapy
Humanized Monoclonal Antibodies
Asthma
Diabetes type 1
Eye Disorders
Hodgkin lymphoma
Immunosuppression
Leukemia-lymphoma, adult T-cell
Multiple sclerosis
Multiple sclerosis, relapsing-remitting
Psoriasis
Transplant rejection
Transplant rejection, heart
Transplant rejection, kidney
Ulcerative colitis
Uveitis
Biotest (Originator)
ElsaLys Biotech
Jazz Pharmaceuticals
OPi (Jazz Pharmaceuticals)
Pre-Registered Murine Monoclonal Antibodies Graft-versus-host disease
Mabpharm
Mabtech (Sinomab)
Sinomab (Originator)
Sorrento Therapeutics
TNK Therapeutics
Phase III Chimeric Monoclonal Antibodies
Follow-on Products
Transplant rejection
Second Xiangya Hosp Central South Univ (Originator) Phase II IL-2
Polypeptides, from 41 AA
Recombinant proteins
Pemphigus vulgaris
Urticaria
Lilly
Nektar Therapeutics (Originator)
Phase II IL-2
Pegylated Drugs
Polypeptides, from 41 AA
Recombinant proteins
Alopecia areata
Atopic dermatitis
Autoimmune disease
Crohn's disease
Graft-versus-host disease
Plaque psoriasis
Rheumatoid arthritis
Systemic lupus erythematosus
Ulcerative colitis
Bioniz Therapeutics (Equillium)
Equillium (Originator)
Phase II Pegylated Drugs
Peptides
Alopecia areata
Atopic dermatitis
Cutaneous T-cell lymphoma
HTLV-1-associated myelopathy-tropical spastic paraparesis
Large granular lymphocytic leukemia
Lymphocytic leukemia
Vitiligo
University of California Los Angeles (Originator) Phase II Transplant rejection
National Cancer Institute (Originator) Phase II Fusion Proteins
Immunotoxins
Polypeptides, from 41 AA
Toxins
Chronic lymphocytic leukemia
Cutaneous T-cell lymphoma
Hairy cell leukemia
Leukemia
Lymphoma
Melanoma

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

As an established leader in the antibody industry, Creative Biolabs consistently integrates innovative technologies and specialized knowledge to enhance the quality and efficacy of our products. If you're seeking dependable IL2RB antibody solutions, don't hesitate to reach out to us for further information and assistance.

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