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INCENP
Anti-INCENP Recombinant Antibody Products
- PE-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer (MHC-LC839)
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- Class: Class I
- Antigen: INCENP
- Antigen Species: Human
- Peptide: REFSKEPEL
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Squamous epithelial cells)
Immune cell specificity
Group enriched (basophil, NK-cell)
Cell line specificity
Low cell line specificity
Interaction
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex binds directly to AURKB or AURKC via the IN box, and forms a triple-helix bundle-based subcomplex with BIRC5 and CDCA8 via its N-terminus (PubMed:17956729, PubMed:27332895). The reported homodimerization is questioned as the SAH domain is shown to be monomeric (By similarity). Interacts with H2AZ1 (By similarity). Interacts with CBX1 and CBX3. Interacts with tubulin beta chain. Interacts with EVI5. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5; regulates INCENP (and probably CPC) localization to centromeres in interphase and not required for proper mitotic progression or sister chromatid cohesion. Interacts with POGZ. Interacts with JTB.
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