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IRAK2
Anti-IRAK2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
Protein class
Enzymes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Oligodendrocytes, Urothelial cells, Prostatic glandular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BEWO, BJ hTERT+, CAPAN-2, GAMG, RT4)
Interaction
Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.
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Related Signaling Pathways
TLR Signaling Pathway