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ITGA1
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
Protein class
Cancer-related genes, CD markers, Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Adipocytes, Smooth muscle cells, Endothelial cells, Hepatocytes, Sertoli cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (fHDF/TERT166, HHSteC, SH-SY5Y, WM-115)
Interaction
Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.
Molecular function
Integrin, Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Rat
- Type: Mouse scFv
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Rat
- Type: Mouse Fab
- Application: ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Rat
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-ITGA1 Recombinant Antibody; Fab Fragment (PABX-188-F (E)) (PABX-188-F (E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
- Recombinant Mouse Anti-Integrin alpha 1 Antibody Fab Fragment (AQC2) (PABX-121-F (E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, Neut, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, IHC, IP
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, Neut, FuncS
- Mouse Anti-ITGA1 Antibody (clone mAb6), mRNA (PABC-132-mRNA)
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- Species Reactivity: Human
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, Neut, FuncS
- Recombinant Mouse Anti-ITGA1 Antibody (5E8D9) (NEUT-1541CQ)
-
- Species Reactivity: Human
- Type: IgG2a
- Application: Neut, ICC/IF
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-ITGA1 Recombinant Antibody (clone 3.40); scFv Fragment (HPAB-1764-FY-F(E))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FuncS
- Human Anti-ITGA1 Recombinant Antibody (clone 7.22); scFv Fragment (HPAB-1766-FY-F(E))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FuncS
- Human Anti-ITGA1 Recombinant Antibody (clone 2.19); scFv Fragment (HPAB-1765-FY-F(E))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FuncS
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For Research Use Only. Not For Clinical Use.