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ITGB5
This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A549, hTERT-RPE1, WM-115)
Interaction
Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with CCN3 (PubMed:15611078). (Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein.
Molecular function
Host cell receptor for virus entry, Integrin, Receptor
More Types Infomation
- Recombinant Mouse Anti-Human ITGB5 Antibody (MOB-2026MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, ICC, IHC, IP
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- Species Reactivity: Human, Hamster, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.