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ITGB8

Anti-ITGB8 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


ITGB8 (Integrin Subunit Beta 8) is a Protein Coding gene. Diseases associated with ITGB8 include Hypoplastic Right Heart Syndrome and Arteriovenous Malformation. Among its related pathways are Beta-Adrenergic Signaling and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and extracellular matrix protein binding. An important paralog of this gene is ITGB3.
Protein class

Cancer-related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Oligodendrocyte precursor cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enhanced (AF22, EFO-21, RPTEC TERT1, WM-115)

Interaction

Heterodimer of an alpha and a beta subunit (PubMed:1918072). Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8 (PubMed:1918072, PubMed:22278742). ITGAV:ITGB8 interacts with TGFB1 (PubMed:22278742).

Molecular function

Integrin, Receptor

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