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ITGB8

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For Research Use Only. Not For Clinical Use.


Background

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Protein class

Cancer-related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Oligodendrocyte precursor cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enhanced (AF22, EFO-21, RPTEC TERT1, WM-115)

Interaction

Heterodimer of an alpha and a beta subunit (PubMed:1918072). Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8 (PubMed:1918072, PubMed:22278742). ITGAV:ITGB8 interacts with TGFB1 (PubMed:22278742).

Molecular function

Integrin, Receptor

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