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ITGB6
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Spermatocytes, Alveolar cells type 2, Pancreatic endocrine cells, Alveolar cells type 1, Basal prostatic cells, Urothelial cells, Basal respiratory cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CAPAN-2, RPTEC TERT1)
Interaction
Heterodimer of an alpha and a beta subunit (PubMed:11807098, PubMed:17545607, PubMed:17158881). Interacts with FLNB (PubMed:11807098). Interacts with HAX1 (PubMed:17545607). ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881). ITGAV:ITGB6 interacts with TGFB1 (PubMed:22278742, PubMed:28117447). (Microbial infection) Integrin ITGAV:ITGB6 interacts with coxsackievirus A9, coxsackievirus B1 capsid proteins (PubMed:9426447, PubMed:15194773). (Microbial infection) Integrin ITGAV:ITGB6 interacts with herpes simplex virus-1/HHV-1 gH:gL proteins.
Molecular function
Host cell receptor for virus entry, Integrin, Receptor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
- Human Anti-ITGB6 Recombinant Antibody; Fab Fragment (HPAB-1772-FY-F(E)) (HPAB-1772-FY-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Block
- Human Anti-ITGB6 Recombinant Antibody (HPAB-1772-FY) (HPAB-1772-FY)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: Inhib, IHC
- Human Anti-ITGB6 Recombinant Antibody; scFv Fragment (HPAB-1772-FY-S(P)) (HPAB-1772-FY-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Block
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For Research Use Only. Not For Clinical Use.