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JAK3

Engineered Antibody
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Protein class

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (T-cells, B-cells, dendritic cells, NK-cells, Plasma cells, Macrophages)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HDLM-2, HEL, HMC-1, Karpas-707, U-266/70, U-266/84, U-937)

Interaction

Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.

Molecular function

Kinase, Transferase, Tyrosine-protein kinase

More Types Infomation
Related Diseases
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Pancreatic Cancer Pancreatic Cancer
Primary Immunodeficiency Primary Immunodeficiency

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