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JARID2
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- Recombinant Anti-mouse JARID2 Antibody (MOB-594)
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- Derivation: Mouse
- Species Reactivity: mouse
- Type: IgG
- Application: ELISA, WB, IP, FuncS
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- Recombinant Human Anti-mouse JARID2 Antibody Fab Fragment (MHH-594-F(E))
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- Derivation: Human
- Species Reactivity: mouse
- Type: Fab
- Application: FC, Neut, Funcs
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- Recombinant Human Anti-mouse JARID2 Antibody scFv Fragment (MHH-594-S(P))
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- Derivation: Human
- Species Reactivity: mouse
- Type: scFv
- Application: ELISA, WB, FuncS
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- Recombinant Anti-mouse JARID2 Antibody Fab Fragment (MOB-594-F(E))
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- Derivation: Mouse
- Species Reactivity: mouse
- Type: Fab
- Application: IF, WB, FuncS
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- Recombinant Anti-mouse JARID2 Antibody scFv Fragment (MOB-594-S(P))
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- Derivation: Mouse
- Species Reactivity: mouse
- Type: scFv
- Application: FC, WB, FuncS
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- Rabbit Anti-JARID2 Recombinant Antibody (VS13-YC611) (VS13-YC611)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
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- Mouse Anti-JARID2 Recombinant Antibody (clone 7H1B3) (VS7-0425-WR169)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ICC, FC
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- Anti-JARID2 Immunohistochemistry Kit (VS-0525-XY3692)
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- Species Reactivity: Human
- Target: JARID2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Protein class
Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (JURKAT, SuSa)
Interaction
Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:29499137, 31959557). Found in a monomeric PRC2. 2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (PubMed:29499137). Facilitates nucleosome binding of the PRC2 complex (PubMed:29499137). Interacts with SUZ12 (via C2H2-type zinc finger domain); the interaction is direct; competes with EPOP for SUZ12 binding (PubMed:29499137). Interacts with histone methyltransferases EHMT1/GLP1 and EHMT2/G9a (By similarity). Interacts with GATA4 (via the N-terminal region) (By similarity). Interacts with NKX2-5 (via the C-terminal region) (By similarity). Interacts with RB1 (By similarity). Interacts with ZNF496 (By similarity). Interacts with ESRRB (By similarity).
Molecular function
Chromatin regulator, Developmental protein, Repressor
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