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KLRD1
Anti-KLRD1 Recombinant Antibody Products
- Recombinant Mouse Anti-KLRD1 Antibody (CBL327) (NEUT-1659CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: BL, FC, CyTOF
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- CytoStream™ Rat Anti-KLRD1 Recombinant Antibody (clone 18d3) (VS-0225-XY156)
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- Species Reactivity: Mouse
- Type: Rat IgG2a, kappa
- Application: FC
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For Research Use Only. Not For Clinical Use.
KLRD1 encodes a protein that is part of the family of killer-cell lectin-like receptors (KLRs), which are expressed on the surface of immune cells like natural killer (NK) cells. KLRD1 interacts with other cell surface molecules to modulate immune responses, particularly in identifying and killing infected or tumor cells. It is involved in both innate and adaptive immunity. KLRD1 plays a role in the recognition of altered self-cells and is important in the defense against infections and malignancies.
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (NK-cells, dendritic cells, T-cells)
Immune cell specificity
Group enriched (NK-cell, gdT-cell, naive CD8 T-cell, memory CD8 T-cell)
Cell line specificity
Low cell line specificity
Interaction
Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2 (PubMed:18083576, PubMed:18332182, PubMed:18448674, PubMed:9655483). KLRD1-KLRC1 heterodimer interacts with peptide-bound HLA-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). KLRD1-KLRC1 interacts with much higher affinity with peptide-bound HLA-E-B2M than KLRD1-KLRC2 (PubMed:9486650, PubMed:10428963). Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation (PubMed:9655483, PubMed:15940674).
Molecular function
Receptor
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