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KLRD1
Loading...Anti-KLRD1 Products
- Recombinant Mouse Anti-KLRD1 Antibody (CBL327) (NEUT-1659CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: BL, FC, CyTOF
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- CytoStream™ Rat Anti-KLRD1 Recombinant Antibody (clone 18d3) (VS-0225-XY156)
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- Species Reactivity: Mouse
- Type: Rat IgG2a, kappa
- Application: FC
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- Mouse Anti-KLRD1 Monoclonal Antibody (VS7-0425-WR239) (VS7-0425-WR239)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FC, ELISA
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- Anti-KLRD1 Immunohistochemistry Kit (VS-0525-XY3815)
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- Species Reactivity: Human
- Target: KLRD1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (NK-cells, dendritic cells, T-cells)
Immune cell specificity
Group enriched (NK-cell, gdT-cell, naive CD8 T-cell, memory CD8 T-cell)
Cell line specificity
Low cell line specificity
Interaction
Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2 (PubMed:18083576, PubMed:18332182, PubMed:18448674, PubMed:9655483). KLRD1-KLRC1 heterodimer interacts with peptide-bound HLA-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). KLRD1-KLRC1 interacts with much higher affinity with peptide-bound HLA-E-B2M than KLRD1-KLRC2 (PubMed:9486650, PubMed:10428963). Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation (PubMed:9655483, PubMed:15940674).
Molecular function
Receptor
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