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KRT2

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Suprabasal keratinocytes)

Immune cell specificity

Immune cell enhanced (naive CD4 T-cell)

Cell line specificity

Cell line enhanced (HEL)

Interaction

Heterotetramer of two type I and two type II keratins. Associates with KRT10 (By similarity).

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