LHX3

This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]LHX3 (LIM Homeobox 3) is a Protein Coding gene. Diseases associated with LHX3 include Pituitary Hormone Deficiency, Combined, 3 and Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function. Among its related pathways are DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and transcription factor activity, RNA polymerase II transcription factor binding. An important paralog of this gene is LHX4.Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.