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    LMO2

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    For Research Use Only. Not For Clinical Use.


    Background

    LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.
    Protein class

    Cancer-related genes, Disease related genes, Human disease related genes

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Hepatic stellate cells, Endothelial cells, Adipocytes, Erythroid cells, Kupffer cells, Microglial cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (HEL, HL-60, K-562, NB-4, THP-1, U-937)

    Interaction

    Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.

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