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M2 protein

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For Research Use Only. Not For Clinical Use.


Background

The influenza A virus M2 protein is an integral membrane protein that functions as a proton-selective ion channel. It plays a crucial role in the viral replication cycle, particularly in the process of viral uncoating within endosomes. It is essential for maintaining the proper pH balance within the virus during its entry into host cells. The M2 protein is also a target for antiviral drugs, such as amantadine and rimantadine, although resistance to these drugs has become widespread. It is a homotetramer, meaning it is made up of 4 identical M2 protein subunits.
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