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MAF
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatic stellate cells, Kupffer cells, Inhibitory neurons, Proximal enterocytes, Hofbauer cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Group enriched (Karpas-707, RPMI-8226)
Interaction
Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction takes place weakly in normal T-cells and increases in T-cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complex formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1 (By similarity).
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Species Reactivity: Human
- Application: WB
- Rabbit Anti-MAF Recombinant Antibody; scFv Fragment (HPAB-693-FY-S(P)) (HPAB-693-FY-S(P))
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- Species Reactivity: Human
- Type: Rabbit scFv
- Application: WB, ELISA
- Rabbit Anti-MAF Recombinant Antibody (HPAB-693-FY) (HPAB-693-FY)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, SPR
- Recombinant Anti-human Maf Intrabody [Tat] (IAB-B020(T))
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- Species Reactivity: human
- Type: scFv-Tat
- Application: CO-IP, FuncS
- Recombinant Anti-human Maf Intrabody [+36 GFP] (IAB-B020(G))
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: FC, IF, FuncS
- Recombinant Anti-human Maf Intrabody [(D-Arg)9] (IAB-B020(A))
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: IF, ELISA, FuncS
- Rabbit Anti-MAF Recombinant Antibody; Fab Fragment (HPAB-693-FY-F(E)) (HPAB-693-FY-F(E))
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- Species Reactivity: Human
- Type: Rabbit Fab
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.