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MAGEA3

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Group enriched (Spermatogonia, Spermatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (GAMG, K-562, OE19, PC-3, SH-SY5Y, SK-BR-3, U-266/70, U-266/84)

Interaction

Interacts with TRIM28.

Molecular function

Tumor antigen

More Types Infomation

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