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    MAPK7

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
    Protein class

    Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Spermatocytes)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (ASC diff, SuSa)

    Interaction

    Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6. Interacts (via N-terminal half) with HSP90AB1-CDC37 chaperone complex in resting cells; the interaction is MAP2K5-independent and prevents MAPK7 from ubiquitination and proteasomal degradation (PubMed:23428871).

    Molecular function

    Kinase, Serine/threonine-protein kinase, Transferase

    More Types Infomation
    Related Signaling Pathways
    FcεR1 Signaling Pathway FcεR1 Signaling Pathway
    TCR Signaling Pathway TCR Signaling Pathway
    Related Diseases
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young
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