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MCM3
Anti-MCM3 Recombinant Antibody Products
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- Mouse Anti-MCM3 Recombinant Antibody (VS3-CJ819) (VS3-CJ819)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ICC, IF, IHC, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
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- Anti-MCM3 Immunohistochemistry Kit (VS-0325-XY1320)
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- Species Reactivity: Human, Mouse, Rat
- Target: MCM3
- Application: IHC
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- Rabbit Anti-MCM3 Recombinant Antibody (VS13-YC713) (VS13-YC713)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Protein class
Cancer-related genes, Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Erythroid cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the MCM2-7 complex (PubMed:16899510, PubMed:17296731). The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (PubMed:16899510, PubMed:17296731). Associated with the replication-specific DNA polymerase alpha (By similarity). Interacts with MCMBP (PubMed:17296731). Interacts with ANKRD17 (PubMed:23711367). Interacts with MCM3AP isoform MCM3AP; this interaction leads to MCM3 acetylation (PubMed:9712829, PubMed:11258703, PubMed:12226073). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
Molecular function
DNA-binding, Helicase, Hydrolase
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