MDK

Tetramer Products AbPlus Recombinant Antibody Products Functional Antibody Products Formats

Anti-MDK Recombinant Antibody Products

Afuco™ Anti-Human MDK ADCC Recombinant Antibody, ADCC Enhanced (AFC-499CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
Compare

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Protein class

Cancer-related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Paneth cells, Enteroendocrine cells, Proximal enterocytes, Granulosa cells)

Immune cell specificity

Immune cell enhanced (neutrophil, memory B-cell)

Cell line specificity

Cell line enhanced (NTERA-2, REH, SH-SY5Y)

Interaction

Homodimer. Interacts with ALK (PubMed:12122009). Interacts with LRP1; promotes neuronal survival (PubMed:10772929). Interacts with LRP2 (PubMed:10772929). Interacts with NCAM1 (PubMed:10772929). Interacts (via C-terminal) with PTPRZ1 (via chondroitin sulfate chains); this interaction is inhibited by PTN; this interaction promotes neuronal migration (PubMed:10212223). Interacts with NCL; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (PubMed:12147681). Interacts with LRP6 and LRP8: this interaction is calcium dependent (PubMed:12573468). Interacts with ITGA4 (PubMed:15466886). Interacts with ITGA6 (PubMed:15466886). Interacts with ITGB1 (PubMed:15466886). Interacts with ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Interacts with ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886). Interacts with NOTCH2; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (PubMed:18469519). Interacts with GPC2 (via heparan sulfate chain); this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Interacts with SDC3; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Interacts with SDC1 (By similarity). Interacts with CSPG5; this interaction promotes elongation of oligodendroglial precursor-like cells (By similarity).

Molecular function

Developmental protein, Growth factor, Heparin-binding, Mitogen

More Types Infomation