Cancer-related genes, Disease related genes, Human disease related genes
Intracellular, Membrane (different isoforms)
Cell type enhanced (Spermatocytes, Excitatory neurons)
Low immune cell specificity
Low cell line specificity
Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L; this interaction also occurs with the KMT2A/MLL1 fusion protein. Interacts with histone H3; interaction is necessary for MLLT10 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3) amd acetylation; interaction stabilizes association of MLLT10 at chromatin; interaction is essential for histone H3 'Lys-79' dimethylation (H3K79me2) (PubMed:26439302).
DNA-binding
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For Research Use Only. Not For Clinical Use.