MTA2

This gene encodes a protein identified as a component of NuRD (Nucleosome Remodeling Deacetylase), a complex found within the nucleus of human cells. It exhibits a very broad expression pattern, with strong expression observed across numerous tissues. This protein may be part of a small gene family whose members encode distinct yet related proteins involved either directly or indirectly in transcriptional regulation, potentially including roles in chromatin remodeling. It shares close homology with another family member that has been correlated with the metastatic potential of certain carcinomas. Both proteins possess similar domain architectures, including two DNA binding domains, a dimerization domain, and a domain commonly found in DNA methylating proteins. One known target protein for this gene product is p53. The deacetylation of p53 is associated with a loss of growth inhibition in transformed cells, which supports a connection between these gene family members and metastasis.