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MZB1

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For Research Use Only. Not For Clinical Use.


Background

Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
Predicted location

Secreted

Single cell type specificity

Cell type enriched (Plasma cells)

Immune cell specificity

Group enriched (plasmacytoid DC, memory B-cell)

Cell line specificity

Group enriched (Karpas-707, RPMI-8226)

Interaction

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner (By similarity).

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