Matriptase

Methoxy tryptase (Matriptase) is a protein, it first checks in a mouse thymic epithelial cells. Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Further, methoxy tryptase (Matriptase) is also isolated from the human cell carcinoma cell was named as methoxy tryptase (Matriptase), MT-SP1 or ST14 and the like. Tome tryptase (Matriptase) has been its expression is markedly increased in most epithelial-derived cancer cells, including ovarian cancer, prostate cancer, cervical cancer, breast cancer, also became known in recent years for expression in macrophages. Methoxy tryptase (Matriptase) is a functionally type II membrane protease (type II transmembrane serine protease), is known to be involved in the normal epithelial cell differentiation and cancer.