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MRAS

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Theca cells, Distal tubular cells)

Immune cell specificity

Immune cell enriched (non-classical monocyte)

Cell line specificity

Cell line enhanced (BJ, EFO-21, fHDF/TERT166)

Interaction

Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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