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MSLN

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Mesothelin is a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, IHC, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
Mesothelin
Linker:
Cleavable, disulfide
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
MSLN
Linker:
protease-cleavable peptide linker
Drug:
MMAE (Monomethyl auristatin E)
Target:
mesothelin
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
mesothelin
Target:
MSLN
Linker:
mc (maleimidocaproyl)
Drug:
MMAF (monomethyl auristatin F)
Target:
MSLN
Linker:
mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug:
MMAE (monomethyl auristatin E)
Target:
MSLN
Linker:
mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug:
MMAF (monomethyl auristatin F)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, IHC, FC, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Mouse
Application:
Cytotoxicity assay, Function study
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Human phage display library
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Human phage display library
Species Reactivity:
Mouse
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Type:
Mouse antibody
Application:
FC, IHC-Fr, WB
Species Reactivity:
Human
Type:
Chicken antibody
Application:
WB
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